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Document Type

Original Study

Abstract

Background: Anterior cruciate ligament injury patients' (ACL), meniscus, and collateral ligament tears are typical knee injuries. These injuries cause knee osteoarthritis and impede exercise. Knee stability comes from the ACL. Thrust or pace changes in sports may harm healthy young knees. Injuries primarily affect knee mobility and stability. The structural and functional changes in anterior cruciate ligament injury and rehabilitation are assessed using MRI and approved clinical imaging. Vital signs and an MRI may assess tissue inflammation and healing before and after surgery.

Objective: The study aimed to examine if IL-6 and IL-13 levels could be associated with the risk of ACL

Materials and Methods: 120 participants—60 controls and 60 anterior cruciate ligament damage patients. They had 67 males and 53 females. Participants were 18–75 years old. This case-control study included patients at Al-Furat Al-Awsat and Royal Private Hospitals in Al-Diwaniyah Governorate, Iraq, from November 2022 to May 2023. Eliza and Elabscience kits were used to analyze IL-6 and IL-13. All patients were biochemically tested before and six weeks after ACLR. The Al-Qadisiyah University College of Medicine's Department of Medical Chemistry lab performed the tests.

Results:The study found a significant increase in serum biomarker Interleukin-6 (IL-6) levels in patients with anterior cruciate ligament injuries after surgery (6 weeks) compared to the control group (P

Conclusion: We found that IL-6 and IL-13 may induce inflammation causing synovitis. High levels of these substances after an ACL injury may lead to continued inflammation and the development of post-traumatic osteoarthritis.

Keywords

Anterior cruciate ligament injury, Interleukin-6 (IL-6), and interleukin 13 (IL-13)

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