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Document Type

Original Study

Abstract

This study investigate the anti-hyperglycemic effect of Desplatsia dewevrei seed methanol extract in diabetic rats. A standard protocol was modified using forty (40) Wistar rats in five groups. The standard control (10 mg/kg Glibenclamide), the untreated control group (45 mg/kg streptozotocin) (STZ), and graded doses (30, 50 and 100 mg/kg) of D. dewevrei seed methanol extract were administered after inducing diabetes. The blood glucose level were observed in days 1, 7 and 14. The animals were sacrificed, blood and organ samples were isolated and analyzed for their biochemical and histopathological evaluations. The results obtained showed a significant decrease in the blood sugar level at graded doses specifically in 14 days after treatment (46, 47.67 and 68 mg/dl). The body and organ weight, kidney function and lipid profile test elicited no significant different across the doses, with normal physiological state when compared with the control groups (p < 0.05, 0.01). Graded doses of D. dewevrei seed methanol extract exhibited a protective effects on the organs (pancreas, liver, spleen, lungs, heart, kidney and ovary), which elicited no deformities or malfunctioning of the organs when compared with the control. In conclusion, Desplatsia dewevrei possessed therapeutic property, which adhere to the folklore report.

Keywords

Hyperglycemic, Desplatsia dewevrei, Diabetic, Wistar Rats

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