Document Type
Original Study
Abstract
Aspergillus Fumigatus is an opportunistic fungal pathogen that causes a range of infections in humans, particularly in immunocompromised individuals. In this study, we investigated the therapeutic potential of A. bisporus extract for treating A. fumigatusinduced pulmonary infection in mice. Mice were inoculated with A. fumigatus and then treated with A. bisporus extract for 21 days. We found that A. bisporus extract and voriconazole treatments affect WBC count, with the extract-treated groups and voriconazole-treated group showing lower counts compared to infected mice without treatment, A. bisporus extract-treated groups display higher RBC counts, while voriconazole treatment results in lower RBC count compared to infected mice without treatment. Lastly, voriconazole treatment decreases IFN-γ levels, while treatment with the mushroom extract slightly increases IFN-γ levels. The findings suggest that A. bisporus extract and voriconazole may influence immune response parameters and infection control. The extract shows potential immunomodulatory effects, as evidenced by alterations in WBC count, LYM levels, and RBC count. Voriconazole, on the other hand, affects WBC count, RBC count, and IFN-γ levels, indicating potential immune modulation.
Keywords
A. fumigatus, COVID-19, A. bisporus, antifungal activity
Recommended Citation
Jawad, Athraa Abbass and Jasim, Neeran Obied
(2024)
"Effect of alcoholic extract of Agaricus Bisporus on blood profiles and immune response in rats with aspergillosis,"
Al-Qadisiyah Journal of Pure Science: Vol. 29
:
No.
1
, Article 7.
Available at:
https://doi.org/10.29350/2411-3514.1228
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