ANTIPYRETIC, ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF POLYHERBAL FORMULATION (AGBO-IBA PMII) USED IN THE TREATMENT OF MALARIA IN SOUTHERN NIGERIA

Pass Chidiebere Chijindu, Department of Biological Sciences, University of Delta, Agbor, Delta State, NigeriaFollow
MacDonald Idu, Department of Plant Biology and Biotechnology, University of Benin, Benin City, Edo State, Nigeria
Benjamin Ogunma Gabriel, Department of Science Laboratory Technology, University of Benin, Benin City, Edo State, Nigeria

Document Type

Original Study

Abstract

The ideal antimalarial agent should not only possess antiplasmodial effects but also anti-inflammatory, antipyretic and analgesic activities. Hence, the aims of were to investigate the antipyretic, anti-inflammatory and analgesic activities of a traditional polyherbal formulation (Agbo-Iba PMII) used to treat malaria in Southern Nigeria. The antipyretic activity was determined by employing three models viz Yeast-induced hyperthermia, D-Amphetamine-induced hyperthermia and 2, 4- Dinitrophenol-induced hyperthermia. The anti-inflammatory activity was determined by employing the carrageenan induced rat paw oedema assay model. While the analgesic activity was determined by employing three models viz Acetic acid induced writhing, Hot Plate Method and Analgesy-meter Test (Randall- Selitto Test). The findings of this study revealed that ‘Agbo-Iba PMII’ (Formulation 1:1:1:1) demonstrated significant (p < 0.05) dose-related antipyretic, anti-inflammatory and analgesic activities at dosages of 200, 400 and 800 mg/kg tested which may be as a result of synergistic interactions between the constituent plants and various phytochemicals present. The obtained results revealed that the polyherbal remedy (Agbo-Iba PMII) contains potent substances with antipyretic, anti-inflammatory and analgesic effects. Thereby, suggesting that these pharmacological effects are vital to the symptomatic management of malaria feverin Southern Nigeria. It is, therefore, recommended for subsequent development for clinical application in malaria therapy.

Keywords

Antipyretic, Anti-inflammatory, Analgesic, Polyherbal formulation, Southern Nigeria

Recommended Citation

Chijindu, Pass Chidiebere; Idu, MacDonald; and Gabriel, Benjamin Ogunma (2024) "ANTIPYRETIC, ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF POLYHERBAL FORMULATION (AGBO-IBA PMII) USED IN THE TREATMENT OF MALARIA IN SOUTHERN NIGERIA," Al-Qadisiyah Journal of Pure Science: Vol. 29 : No. 1 , Article 9.
Available at: https://doi.org/10.29350/2411-3514.1234