Cu(II), Mn(II), Ni(II) Complexes of Mixed Amodiaquine and Paraaminobenzoic acid: Synthesis, Characterization, Antimicrobial and Toxicological Activities in Wister rats

Mercy O. Bamigboye, Department of Industrial Chemistry, Faculty of Physical Science, University of Ilorin, Ilorin, NigeriaFollow
Ikechukwu P. Ejidike, Department of Chemical Sciences, Faculty of Science and Science Education, Anchor University, Lagos, NigeriaFollow
Abdulbasit A. Aliyu, Department of Pure and Industrial Chemistry, Kogi State University, P.M.B. 1008 Anyigba, Kogi, NigeriaFollow

Document Type

Article

Abstract

Four novel metal complexes of mixed amodiaquine and paraaminobenzoic acid have been synthesized using a standard method and confirmed by results of some physicochemical and spectroscopic techniques. Antimicrobial activities have been carried out on the complexes against some selected organisms: (antibacterial organisms: K. pneumonia, B. subtilis, E. coli, S. aureus, P. aeruginosa and S. faecalis) and (antifungal organisms: Candida albicans, Aspergillus niger and Penicillium chrysogenum) to determine their effectiveness. The complexes were evaluated for their toxicity level in wister rats. The Amodiaquine and Paraaminobenzoic acid produce complexes in ratio 1:1:1 in coordination with the metal ion. Octahedral geometry has been proposed for all the complexes. The complexes were found to be non-electrolytic in nature. The complexes were observed to be more active than their free ligands as determined by their zone of inhibition (nm). The complexes have been proved to be less toxic to the body.

Keywords

Synthesis, Amodiaquine, Antimicrobial

Recommended Citation

Bamigboye, Mercy O.; Ejidike, Ikechukwu P.; and Aliyu, Abdulbasit A. (2020) "Cu(II), Mn(II), Ni(II) Complexes of Mixed Amodiaquine and Paraaminobenzoic acid: Synthesis, Characterization, Antimicrobial and Toxicological Activities in Wister rats," Al-Qadisiyah Journal of Pure Science: Vol. 25 : No. 4 , Article 11.
Available at: https://doi.org/10.29350/qjps.2020.25.4.1184