Synthesis and Characterization of New benzimidazole-nitrone Derivatives and Study of Their Effect as Anti-fungal

Authors

Meaad A. Fadel, Department of chemistry, College of Science, University of Basrah, IraqFollow
Dawood S. Ali, Department of chemistry, College of Science, University of Basrah, IraqFollow
Hanaa K. Mousa, Department of chemistry, College of Science, University of Basrah, IraqFollow

Document Type

Article

Abstract

New benzimidazole derivatives (benzimidazole-nitrone) were synthesized from the condensation of o-phenylene diamine with p-amino benzaldehyde in the presence of (P-TSOH\EtOH) then the benzimidazole compounds that containing an imine group were oxidized to obtain a nitrone group by used peracetic acid and identified by FT-IR, H1-NMR spectra, and elemental analysis. all compounds applied to the candida and aspergillus fungi gave a different result. The compounds have Ph, OH and N(CH3)2 groups as substituted in synthesized benzimidazole derivatives were showed reactivity as anti-fungal.

Keywords

Benzimidazole, nitrone, candida and aspergillus fungi, anti-fungal

Recommended Citation

Fadel, Meaad A.; Ali, Dawood S.; and Mousa, Hanaa K. (2022) "Synthesis and Characterization of New benzimidazole-nitrone Derivatives and Study of Their Effect as Anti-fungal," Al-Qadisiyah Journal of Pure Science: Vol. 27 : No. 1 , Article 26.
Available at: https://doi.org/10.29350/2411-3514.1222

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