"Study The Levels Of Cytokines (IL-12,IFN-γ) And Human Proflin-1 (PFN-1" by Hadeel S. Hadi, Raad A. Kadhim et al.

Article Title

Study The Levels Of Cytokines (IL-12,IFN-γ) And Human Proflin-1 (PFN-1) In The Sera Of Aborted Women With Toxoplasmosis And Healthy Women (non-pregnant and pregnant women)

Authors

Hadeel S. Hadi, College of Science for Women, University of Babylon, Hilla, IraqFollow
Raad A. Kadhim, College of Science for Women, University of Babylon, Hilla, Iraq
Raheem T.O. Al-Mammori, Merjan Medical City, Babylon province, Hilla, Iraq

Document Type

Article

Abstract

Toxoplasma gondiiisan intracellular parasite infected large proportion of the world population, but mostly without visible clinical signs in immunocompetent patients. The present studywasperformedto determinethe levels of cytokines (IL-12 , IFN-γ) and human proflin-1 (PFN-1) in the sera of 60aborted women with seropositive anti-Toxoplasmaantibodies (55 seropositive IgG and 5 seropositive IgM ) as case group and 30 healthy women (15 non pregnantand 15 pregnant women) as control groups in Women's and children Hospital in Al-Qadisiyah province from December / 2015 till March / 2016, Five ml of venous blood sample was obtained from each woman under sterile condition. Serum samples of aborted women were all positive for Toxoplasmaantibodies by ELISA method as a result of a previous study back to us.Cytokines and profilin-1 wereestimated in all samples, a significant increase in the concentration of interleukin-12 was observed in the abortedwomen with toxoplasmosis and a significant decrease in the concentrations of both interferon gamma (IFN-γ)and profilin-1(PFN-1) comparedto the control groupat probability (0.05).These results confirm the overlapping role between Toxoplasmainfection and abortion on immune factors.

Keywords

Toxoplasma gondii, cytokines (IL-12, IFN-γ) and human proflin-1 (PFN-1)

Recommended Citation

Hadi, Hadeel S.; Kadhim, Raad A.; and Al-Mammori, Raheem T.O. (2021) "Study The Levels Of Cytokines (IL-12,IFN-γ) And Human Proflin-1 (PFN-1) In The Sera Of Aborted Women With Toxoplasmosis And Healthy Women (non-pregnant and pregnant women)," Al-Qadisiyah Journal of Pure Science: Vol. 26 : No. 4 , Article 17.
Available at: https://doi.org/10.29350/qjps.2021.26.4.1352