Spectrophotometric Determination Of Valsartan In Pure Form And In Its Pharmaceutical Preparations

Ruwaida Farman Salih, College of Education for pure science, Tikrit University,Follow
Qabas Naji Rashid, Asst. prof. of Analytical Chem., College of Education for pure science, Tikrit UniversityFollow

Document Type

Article

Abstract

An easy, rapid and economical spectrophotometric method for determination of Valsartan (Val), by reaction with 4-chloro-7-nitrobenzofurazan (NBD-Cl) as reagent in an alkaline interemediate. This method is based on the forming of product between (Val) and the chromogenic reagent (NBD-Cl), to produce a brown color at (pH 11.9) and λmax. 470 nm. Beer’s Law is obeyed at the concentrations range of (0.4-14.8 µg/ml), with molar absorptivity of (1.05×104 L/mol.cm) and correlation coefficient 0.9827, The limit of detection was 0.557 µg/ml. The suggested method was prosperity implement to the determination of (Val) in pure form and in its pharmaceutical formulations (tablets).

Keywords

spectrophotometric, Valsartan, NBD-Cl

Recommended Citation

Salih, Ruwaida Farman and Rashid, Qabas Naji (2021) "Spectrophotometric Determination Of Valsartan In Pure Form And In Its Pharmaceutical Preparations," Al-Qadisiyah Journal of Pure Science: Vol. 26 : No. 4 , Article 27.
Available at: https://doi.org/10.29350/qjps.2021.26.4.1317