Synthesis And Characterization ( Oxazepine , Thiazine and Quinazoline ) Derivatives And Study The Biological Activity As Antibacterial

Adel Jasim, Department of chemistry, College of Education for, Al-Qadisiyah UniversityFollow
Shaimaa Adnan, Department of chemistry, College of Education for, Al-Qadisiyah UniversityFollow

Document Type

Article

Abstract

This research. Included the preparation. and characterization some novel. Six and seven membered Heterocyclic. Compounds ( oxazepine , thiazine , quinazoline ) The first step in clode react 2-amino-6- methoxybenzothiazole with 4- amino acetophenone to get Schiff base derivative (1). The second step react (1) with 4 -hydroxy acetophenone to get schiff base derivative (2) the last step involve react (2) with ( Phthalic , Maleic , Succinic) anhydride to .get oxazepine derivatives (3,4and 5) also react (2) with(2-amino benzoic acid) and (2-mercaptobenzoic acid ) to get quinazoline (6)and thiazine (7) derivatives respectively .the physical; properties of the prepared; These Compounds. Were Identification (FT-IR) ,(1H-NMR) and (13C-NMR) by spectroscopy thene study their biological effect on two types of bacteria Staphylococcus aureuses (Gram positive) and Escherichia coli (Gram Negative)

Keywords

schiff base, Oxazepine, Quinazoline, Thiazine

Recommended Citation

Jasim, Adel and Adnan, Shaimaa (2021) "Synthesis And Characterization ( Oxazepine , Thiazine and Quinazoline ) Derivatives And Study The Biological Activity As Antibacterial," Al-Qadisiyah Journal of Pure Science: Vol. 26 : No. 4 , Article 37.
Available at: https://doi.org/10.29350/qjps.2021.26.4.1335