Synthesis Of Fused Dihydrobenzo [4,5] Imidazo [1,2-a] Pyrmido [5,4-e] Pyrmidin-3 (4H)-amine Derivatives

Fadhel R. Hafedh, mustansiriyah univeristy, college of science, department of chemistry
Hamid H. Mohammed
Zainab N. Mageed

Document Type

Article

Abstract

Some of fused dihydrobenzo [4,5]imidazo [1,2-a] pyrmido [5,4-e] pyrmidin-3(4H)-amine derivatives were synthesized, theses derivatives derived from 4-amino-2-(4-chloro or bromophenyl) -1,2-dihydropyrimido[1,2-a] benzimidazole-3-carbonitrile (4,5), which prepared by reaction 1H-benzimidazol-2-amine (1) and p-chlorobenzaldehyde or p-bromobenzaldehyde (2) and malononitrile (3). These derivatives prepared by reaction compound (4,5) with with triethylorthoformate in presence acetic anhydride to give the products (6,7), then the products was reacted with aliphatic amines (hydrazine, methyl amine, ethyl amine, propyl amine and isobutyl amine) to give pyrmidin rings (8-17) respectively. All these derivatives characterization by FT-IR , HNMR spectra and physical properties.

Keywords

pyrmidines, benzimidazole

Recommended Citation

Hafedh, Fadhel R.; Mohammed, Hamid H.; and Mageed, Zainab N. (2021) "Synthesis Of Fused Dihydrobenzo [4,5] Imidazo [1,2-a] Pyrmido [5,4-e] Pyrmidin-3 (4H)-amine Derivatives," Al-Qadisiyah Journal of Pure Science: Vol. 26 : No. 4 , Article 6.
Available at: https://doi.org/10.29350/qjps.2021.26.4.1371